Completed Infection & Immunity Public Health & Healthcare

The African coaLition for Epidemic Research, Response and Training, Clinical Characterization Protocol (ALERRT CCP)

In plain English

AI plain-English summary

A clinical research network already operating across sub-Saharan Africa is training local healthcare workers to study COVID-19 as the outbreak unfolds, rather than waiting for outside experts to arrive. The problem is straightforward: when a new infectious disease emerges, clinicians in low- and middle-income countries need to collect data on how it behaves—who gets sick, how severely, what treatments work—while simultaneously treating patients. The World Health Organization’s Africa office is already running infection control and critical care training, but research training has lagged behind. Without it, African countries risk relying on findings from Europe and China, which may not apply to local populations, healthcare systems, or climates. ALERRT, the African coaLition for Epidemic Research, Response and Training, already has the infrastructure and relationships in place. It will work with WHO/AFRO and Africa CDC to train staff in a standardised clinical characterisation protocol endorsed by WHO and already used in China, the UK, and Europe. If successful, this means African clinicians can generate their own evidence on COVID-19 in real time—feeding into global understanding while directly informing local treatment guidelines and outbreak response. The project does not create new science; it builds the human capacity to do it where it is most needed.

View original technical description
As part of the response to the emergence of COVID-19, the World Health Organization Africa Regional Office is organizing various Infection Prevention and Control (IPC) and critical care training activities targeted at Low and Middle-Income countries (LMICs) in Africa. While the initiatives taken by WHO/AFRO are critical, training for research into the disease also needs to be targeted at the same LMICs, because being an Emerging Infectious Disease, we need to “learn-as-we-go”. Clinical research on COVID-19 will have to be closely integrated with the IPC, clinical care, and epidemiological training activities, including use of the WHO First Few X (FFX) Cases and contact investigation protocol for COVID-19. ALERRT proposes to work closely with the WHO/AFRO and Africa CDC and existing networks and structures across Africa and globally to provide the forementioned clinical research training and support. ALERRT is a member of the Global Federation - ISARIC, which has developed a Clinical Characterization protocol for COVID-19. This protocol been endorsed by the WHO and is currently being used in China and across the UK and Europe.Being already established and conducting activities in sub-Sahara Africa, the ALERRT network has the capacity to effectively implement the proposed project.

View the original record at the funder ↗

Researchers

John Amuasi (EPMC Awardee)

Related Research

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Enabling ISARIC Clinical Characterisation Protocol (CCP) roll out in LMICs

Original classification

Research Grant

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