TissueScaffoldSprayer: A novel air stream-based production process for polymeric nanofiber scaffolds for tissue engineering in regenerative medicine.

A new manufacturing process blows polymer nanofibers onto surfaces like a spray painter, building scaffolds that could help the body repair damaged tissues. Tissue engineering needs scaffolds—temporary structures that guide cells to grow into functional tissue. Current methods for making nanofiber scaffolds are slow, expensive, or produce inconsistent results. This project tackles that bottleneck by developing an air stream-based sprayer that deposits polymer nanofibers directly onto a target surface, creating a scaffold with controlled fiber alignment and density. The process is designed to be faster and more scalable than existing techniques. If successful, the TissueScaffoldSprayer could lower the cost and complexity of producing scaffolds for regenerative medicine. Surgeons might one day spray a custom scaffold onto a wound or damaged organ during a procedure, rather than implanting a pre-made structure. The technology could also be adapted for other applications where nanofiber mats are useful, such as wound dressings or drug delivery systems. The project is applied engineering—it aims to solve a specific manufacturing problem with a clear clinical endpoint in mind.