Completed Psychology & Behaviour Brain & Nervous System

University of Newcastle Centre for Brain Ageing & Vitality supported by BBSRC, EPSRC, ESRC and MRC

In plain English

AI plain-English summary

As the UK population lives longer, the new MRC Centre for Brain Ageing and Vitality in Newcastle will investigate why the brain ages and how exercise and diet can keep it healthy. This matters because old age is often linked to poor health, and the greatest risk factor for dementia and Parkinson’s disease is simply being elderly. Researchers still do not understand why the ageing brain becomes vulnerable to these diseases, or how lifestyle choices might slow that process. If the centre succeeds, it could produce clear, evidence-based guidance on how much exercise people need to stay mobile and which dietary ingredients are most protective as they age. This would give older adults and their doctors practical tools to maintain brain and body function longer, potentially delaying or reducing the burden of age-related diseases. The research is a mix of fundamental science—understanding the basic biology of brain ageing—and applied questions about real-world interventions. Past discoveries in fundamental ageing biology have already led to insights into metabolism and inflammation; this centre aims to build on that foundation to improve health in later life.

View original technical description
In the UK there is a major change in the age of the population - we are all living much longer. Unfortunately old age is often associated with poor health. We still do not understand why this. What we want to understand is why the brain ages and how exercise and diet are helpful to healthy ageing of the brain and body. As we get older the thing we often fear is getting dementia, Parkinson’s disease or other age related diseases. Whilst these diseases can also strike relatively young people, the majority of people with these diseases are elderly. What is it about our brains as they age that means that we are at much greater risk of these diseases? Lots of different work has shown that exercise is good for us, but this is particularly true the older we get. It is really important to know how much exercise we should take to keep our muscles strong and make sure we keep mobile as we get older. There are similar findings with different diets, some seem to be much healthier than others – but what are the most important ingredients? The new MRC Centre for Brain Ageing and Vitality in Newcastle is going to try and answer these questions about our ageing brain and our lifestyle.

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Researchers

Doug Turnbull (Principal Investigator)

Related Research

Grants with similar aims, by meaning.

Centre for Ageing and Vitality
NuBrain: UK Consortium for Optimal Nutrition for Healthy Brain Ageing
Brain Plasticity in Later Life: Improving cognitive-motor function
Modelling variability in the social brain across the lifespan
Physiology of cognitive changes in ageing and dementia

Original classification

Research Grant

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