Completed Infection & Immunity Public Health & Healthcare

Integrating Infection Prevention into Health Care Delivery

In plain English

AI plain-English summary

A hospital patient picks up an infection not from the outside world, but from the very place meant to heal them. This grant aims to stop that from happening. Healthcare-associated infections and antibiotic-resistant bacteria kill thousands of patients in the UK each year. Current prevention efforts often fail because they focus only on the bug, not on the complex system of people, processes, and hospital structures that allow infections to spread. This research addresses that gap by treating infection prevention as an organisational problem, not just a medical one. The programme has four linked workstreams. One uses social marketing and behaviour-change techniques to improve how doctors prescribe antibiotics and how staff follow hygiene protocols. Another identifies genetic and patient-level factors that drive the spread of serious infections like MRSA, aiming to develop new diagnostics and vaccines. A third builds better surveillance systems to track infections and antibiotic resistance across both hospitals and GP surgeries. The fourth trains a new generation of clinical academics and managers specifically skilled in infection prevention. If successful, the centre will produce measurable changes: fewer hospital-acquired infections, more rational antibiotic use, and a sustainable workforce that embeds infection control into routine care rather than treating it as an afterthought.

View original technical description
This grant puts forward a vision to develop an internationally recognised Centre for translational research, training and leadership in Infection Prevention and Management which aims to improve health systems, healthcare delivery and directly improve patient care and safety. It focuses on the key Public Health priorities in hospitals and healthcare associated infection as well as antibiotic resistance. A large number of different groups based in Imperial College London and Imperial College Healthcare NHS Trust, the UK Health Protection Agency and a commercial partner Dr Foster develop positive interaction, build on a strong local track record for developing an organisational approach to infection prevention within the Imperial Trust. The programme of research has four main workstreams. The first investigates the embedding of infection prevention within NH organisational structures and looks at how best to implement innovation and best practice. It also examines how techniques of social marketing and behaviour change can be used to improve infection control and antibiotic prescribing. The second work stream which involves studies into clinical infection, molecular epidemiology, pathogenesis and diagnostics, focuses on identifying factors in the bug and the patient which affect the spread and carriage of serious healthcare associated infection. The aim is to develop new diagnostic tools and ultimately new vaccines and treatments. The third work stream of the project looks at the best way of developing and utilising infection surveillance schemes across primary and secondary healthcare as well as informing the research in work stream two. There will be a focus on surveillance of high risk populations and evaluation of systems to monitor antibiotic resistance and best prescribing practice. The final work stream, is to develop multidisciplinary training to generate a specifically skilled academic and clinical scientific and medical work force to deliver clinical care, research and leadership in infection prevention. Amongst novel approaches being taken includes the focus on e-learning, the development of MSc and short courses and education at PhD level of a series of academic managers. All workstreams have a series of identifiable outputs and their achievement will reflect the success of the research. In the final analysis, overall success will the development of sustainable and internationally recognised centre for infection prevention and management which improves patient outcomes. Alterations in organisational behaviour, new technology, the uptake of innovation, sustainable recruitment and training capacity with continual close working between partner organisations will be further evidence of success.

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Researchers

Alison Holmes (Co-Investigator)Jonathan Friedland (Principal Investigator)Paul Aylin (Co-Investigator)Rifat Atun (Co-Investigator)Shiranee Sriskandan (Co-Investigator)

Related Research

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Original classification

Research Grant

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