Core support for the Wellcome Trust Cancer Research UK Gurdon Institute.

This application requests the continuation of core support to the Wellcome Trust/Cancer Research UK Gurdon Institute, which is an integral part of the University of Cambridge. The aim of the Institute is to contribute to an understanding of normal animal development, including the processes of cell differentiation, proliferation and morphogenesis, and to explain how cancers arise when these processes go wrong. The Institute sets out to achieve these objectives by recruiting excellent scientists and providing them with the best possible environment and facilities for their work. This is made possible by our core funding, which provides technical, administrative and secretarial support to our research groups, as well as expert assistance in bioinformatics, imaging and computing. Core support also ensures that our researchers have access to state of the art facilities, and we are requesting funding for advanced microscopy and high throughput sequencing equipment, and continuing support fo r our mouse facility. Our major goal for the next quinquennium is to produce world class research at the interface between developmental biology and cancer. To achieve this, we will increasingly use genome-wide approaches and quantitative proteomics, and we therefore plan to establish facilities for high throughput sequencing, high content screening, and mass spectroscopy.