Completed Infection & Immunity

World Mosquito Programme

In plain English

AI plain-English summary

A common bacterium, *Wolbachia*, is being deliberately introduced into the mosquitoes that spread dengue, Zika, and chikungunya to stop them from transmitting these viruses to people. This matters because these viral diseases infect millions of people each year in tropical and subtropical regions, and existing control methods—insecticides, bed nets, and behaviour changes—have not stopped their spread. The *Wolbachia* bacterium occurs naturally in many insects but not in the *Aedes aegypti* mosquito that carries these viruses. When the bacterium is introduced into the mosquito population, it reduces the insects’ ability to pass on the viruses. If the technology works as envisioned, it could provide a self-sustaining, area-wide solution. The *Wolbachia* infection spreads through the mosquito population on its own and persists without repeated applications. It also does not require people to change their behaviour—no nets, no repellents, no altered daily routines. The project is now moving beyond small-scale trials to large pilot deployments in significant population centres, while building the infrastructure needed for global rollout. The goal is to demonstrate that the method works at scale and to gather evidence on its actual impact on disease rates.

View original technical description
The World Mosquito Program, formerly known as the Eliminate Dengue Program, is developing a new way to control dengue fever and other diseases caused by arboviruses including Zika and chikungunya. Dengue and these other diseases are caused by different viruses that are transmitted between people by mosquitoes. We have found that a common bacterium (Wolbachia) found in many insects naturally, but not the mosquito that transmits dengue, will reduce the ability of mosquitoes to transmit dengue and other viruses when it is introduced. Initial trials have demonstrated that the Wolbachia technology can be practically deployed at a limited scale, is stable in the field, is acceptable to communities and regulators, and is predicted by modeling to have a major impact on dengue transmission. We are undertaking large scale pilot deployments to demonstrate our ability to implement our Wolbachia vector control measures over significant population centres and also with the aim of providing evidence on disease impact. We are also building the infrastructure needed to support the scale-up and global roll-out of our Wolbachia technology. The technology, if it functions as envisioned, will provide an area-wide solution to the transmission of dengue and other arboviral diseases, capable of spreading and maintaining itself without the need for reapplication and without need for human behavior change.

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Researchers

Scott O'Neill (EPMC Awardee)

Related Research

Grants with similar aims, by meaning.

Development of Wolbachia as an effective and sustainable approach to reduce dengue transmission.
Transitioning the WMP Wolbachia method for arbovirus control to sustainable scale
Wolbachia-mediated arbovirus inhibition in mosquitoes
Optimal deployment of Wolbachia for dengue control
Catalyzing a Global Ecosystem for Scale-up of Wolbachia-based Interventions to Prevent Dengue and Aedes-Borne Diseases

Original classification

Innovations Project Award

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