Completed Cancer Engineering

New minimally invasive technologies for the treatment of pancreatic cancer

In plain English

AI plain-English summary

A fleet of microscopic, magnetically steered robots will snake through the delicate ducts of the pancreas to deliver cancer drugs directly to tumours. This matters because pancreatic cancer is the deadliest common cancer—95% of patients die within two years, and current treatments are brutal. The pancreas is a fragile, deeply buried organ that surgeons cannot easily reach without causing major damage. Existing therapies, such as chemotherapy, poison the whole body and produce severe side effects. The research aims to replace these blunt tools with a precision approach: soft, millimetre-scale robots that can navigate the pancreas’s intricate internal anatomy without cutting into healthy tissue. If the technology succeeds, it could transform pancreatic cancer from a death sentence into a manageable condition. Patients might receive targeted treatment with few side effects, preserving their quality of life. The same robotic platform could also be adapted for earlier diagnosis, catching tumours before they spread. Beyond this single cancer, the fundamental engineering of magnetically controlled soft robots could open new routes for minimally invasive surgery in other hard-to-reach organs, quietly changing how surgeons treat diseases that currently require major operations.

View original technical description
Our vision is to challenge the mind-set of pancreatic cancer being a prognosis of extremely limited options and to enable revolutionary future treatments that will save lives and allow patients to live without major side-effects. Novel engineering and physical science has an essential contribution to make against what is currently the deadliest form of cancer (mortality 95% <2yrs). This research will centre around the creation of new minimally-invasive technologies based on microscale, magnetically-driven, soft continuum robots. These will newly enable non-destructive access to the intricate sensitive internal anatomy of the pancreas and allow targeted treatments to be delivered. These new technologies will tackle current clinical challenges in pancreatic cancer, while also providing the treatment methods that will be required as possibilities for earlier diagnosis emerge in the future.

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Researchers

Giuseppe Tronci (Co-Investigator)Harvey Thompson (Co-Investigator)Jaemin Lee (Co-Investigator)Pietro Valdastri (Co-Investigator)Russell Harris (Principal Investigator)Stephen Russell (Co-Investigator)Thomas Pike (Co-Investigator)

Related Research

Grants with similar aims, by meaning.

MICA: PANC-AID: Engineering a novel dynamic pancreatic cancer organoid model (MICA)
Biophysics of cancer: modelling and assessing physical resistance to therapy
Self-propelled soft robotic endoscopes for next-generation gastrointestinal surgery and beyond
Micro-Robotics for Surgery
Machine-learning guided experimental approaches for developing a robust nanoscale delivery platform for the treatment of pancreatic cancer

Original classification

Research Grant

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